Research Paper Volume 15, Issue 24 pp 15267—15286
Integrative transcriptome and single-cell sequencing technology analysis of the potential therapeutic benefits of oleanolic acid in liver injury and liver cancer
Figure 4. Key targets and protein networks of oleanolic acid (A) High expression of HMOX1, PIM1 and ICAM1 through oleanolic acid-related expression profiles. (B) PPI analysis of 3 key targets of oleanolic acid. (C) Gene function of genes in PPI analysis. (D) Cellular pathways of genes in PPI analysis. (E) GSVA analysis of response to chemical stress in liver injury. (F) GSVA analysis of response to oxidative damage in liver injury. (G) Relationship between key targets of oleanolic acid and 14 oxidative stress pathways in VLJ. (H) Relationship between key targets of oleanolic acid and 14 oxidative stress pathways in TLJ. (I) Relationship between key targets of oleanolic acid and 14 oxidative stress pathways in ALJ. (J) Relationship between key targets of oleanolic acid and 14 oxidative stress pathways in FLJ.