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Research Paper Volume 15, Issue 24 pp 15196—15212

Macrophage-specific deletion of Notch-1 induced M2 anti-inflammatory effect in atherosclerosis via activation of the PI3K-oxidative stress axis

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Figure 7. The PI3K/AKT signaling pathway was involved in the Notch-1MAC-KO-induced M2 polarization and further reduced apoptosis and inflammatory response in AS.