Research Paper Volume 15, Issue 24 pp 14733—14748
Anoikis regulator GLI2 promotes NC cell immunity escape by TGF-β-mediated non-classic hedgehog signaling in colorectal cancer: based on artificial intelligence and big data analysis
Figure 7. ARGs-based AI model recognizes drug efficiency. (A) Drug scores of 5-Fu, L-OHP-1, L-OHP-2, CPT-11 and JQ1 in ARG sub groups, calculated by OncoPredict package in R4.2.0., data from TCGA, (B) GSE39582. (C) Clinical trials response in ARG subpopulations identified by AI. Small molecule inhibitor targets expression level in ARG subpopulations in (D) TCGA cohort and (E) GES39582 cohort. Small molecule inhibitors sensitivity in ARG subpopulations, in which IGFR, EGFR and MAPK inhibitors hold significant differences in (F) TCGA cohort and (G) GSE39582.