Research Paper Volume 15, Issue 23 pp 13888—13900

HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2

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Figure 8. The inhibition of NRF2 reduced the effects of HACE1 in model of heart failure. NRF2 and GPX4 protein expression (A, B), MDA/ROS/SOD/GSH/GSH-PX levels (CG), cell viability (H), LDH activity (I), IL-1α level (J), Iron concentration levels (K), JC-1 disaggregation (L). NRF2 and GPX4 protein expression in blot and immunofluorescence (M, N). ##p<0.01 compared with control group, **p<0.01 compared with HACE1 group.