Research Paper Volume 15, Issue 21 pp 12451—12475
Abnormal low expression of SFTPC promotes the proliferation of lung adenocarcinoma by enhancing PI3K/AKT/mTOR signaling transduction
Figure 4. Development of SFTPC-related risk score using TCGA_LUAD dataset. (A) Venn diagram of DEGs between patients in SFTPC low/high expression subgroups in the TCGA_LUAD and GSE72094 datasets (logFC ≥ 1; adj-P < 0.05). (B, C) LASSO Cox regression model was constructed from 35 DEGs with significant prognostic p-value < 0.01. The 13 essential genes were generated by the optimal profile. (D) Distribution and cutoff value of SFTPC-related risk score. (E, F) OS and survival status of LUAD patients in subgroups with low and high risk. (G) Expression heatmap of the 13 essential genes of patients in TCGA_LUAD cohort.