Research Paper Volume 15, Issue 21 pp 12120—12135
USP14 predicts poorer survival outcomes and promotes tumor progression in endometrial carcinoma by activating NF-κB signaling
Figure 3. Overexpressing USP14 increased EC cell growth in vivo. USP14 overexpression plasmids were introduced into HEC-1-B cells through transfection, and a xenograft tumor model was established. (A) The survival rate of mice in the two groups is shown. (B) Tumor volumes in the nude mice. (C) Tumor images. (D) Tumor weight. (E, F) IHC was conducted to detect KI67 expression, and the KI67-positive cell rate was calculated. (G, H) IHC and WB were conducted to detect USP14 expression. (I, J) The apoptosis- and EMT-associated protein levels in tumor tissues were determined by WB. ***represents P < 0.001, compared to the vector group.