Research Paper Volume 15, Issue 20 pp 10915—10937

The Saccharomyces cerevisiae acetyltransferase Gcn5 exerts antagonistic pleiotropic effects on chronological ageing

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Figure 4. Gcn5 transcriptionally promotes starvation-induced stress response and respiratory metabolisms. (A) Hierarchical clustering of differentially expressed genes regulated by GCN5 at PDS phase (n=594, net log2 Fold change >= 1). (B) A pie chart showing the overlap genes between Cat8-/Adr1-targets and those dependent on Gcn5 in cluster 4. (C) Relative Fbp1-GFP levels in cells grown to glucose starvation; The significance of differences was revealed by two-factor ANOVA analysis for Fbp1-GFP reporters across all the timepoints. ***: p < 0.001, **: 0.001<p< 0.01, *: 0.01<p< 0.05 and n.s.: p> 0.05. Error bars represent standard deviation calculated from biological triplicates.