Research Paper Volume 15, Issue 19 pp 10370—10388
Bridging the gap between clear cell renal cell carcinoma and cutaneous melanoma: the role of SCARB1 in dysregulated cholesterol metabolism
Figure 4. Construction of the cholesterol metabolic prognostic signature. (A) 5 prognostic genes were selected by the univariate Cox regression analysis (p-value < 0.05). (B, C) A 5-mRNA signature was constructed by the LASSO Cox regression. (D) The curve of risk score and survival status of the patients showing a positive correlation between mortality and risk score. (E) The K-M survival curve showing the poorer survival probability of ccRCC patients in the high-risk group (p < 0.001). (F) The heatmap showing the clinicopathological parameters, risk grouping situation, and expression levels of 4 model genes of ccRCC samples. (G) The AUC value of the ROC curve for predicting CM patients’ prognosis, indicating the robustness and accuracy of this 4-mRNA signature. (H, I) Predictive independence assessment of classical clinical predictors and our risk score by the (H) univariate and (I) multivariate Cox regression analysis.