Research Paper Volume 15, Issue 19 pp 10133—10145

Figure 2. SMY prevented DOX-induced cardiomyopathy. (A, B) Cardiac sections were prepared from control mice and mice treated with DOX. SMY-L or SMY-H or mitoTEMPO were treated. The heart tissues were stained with hematoxylin and eosin (H&E, Top) or Sirius red (Bottom). (C) Cardiac collagen quantification (% of collagen of area) in heart tissue. (D) The heart/body weight ratio was calculated in control mice and mice treated with DOX with or without SMY-L or SMY-H or mitoTEMPO (n = 9 mice per group). The results were presented as mean ± SEM. ^##means compared with control group, P < 0.01; ^*means compared with DOX group, P < 0.05, ^**means compared with DOX group, P < 0.01.