Research Paper Volume 15, Issue 21 pp 11697—11719

Figure 1. High expression of hyperphosphorylated tau and total tau was found in P301S Tau mice from early ages. (A, C) Representative Western blots showing ^S202/T205p-tau, ^S214p-tau and total tau in PFC (A) and Hippocampus (C) of WT vs. P301S transgenic mice (WT: n = 3, P301S: n = 4) at 1 month to 6 months of age. (B, D) Plots of quantification data of ^S202/T205p-tau, ^S214p-tau and total tau (normalized to GAPDH) in PFC (B) and Hippocampus (D) of WT vs. P301S mice at various ages. At each time point, ^*p < 0.05, ^**p < 0.01, and ^***p < 0.001, t-test.