Research Paper Volume 15, Issue 17 pp 8993—9021

Figure 8. GO enrichment and genome enrichment analysis. (A) The bubble plot and (B) circos plot showing the significantly enriched GO pathways for DEGs between in TCGA-ESCC dataset. (C) The bubble plot and (D) circle plot presenting the results of GO functional enrichment analysis which standardized by logFC values. (E) Four biological characteristics for Gene sets enriched analysis in TCGA-ESCC dataset. (F–I) The GSEA showed DEGs of TCGA-ESCC dataset significantly enriched in 4 pathways, including the proteasome degradation pathway (F), biocarta classic pathway (G), complement activation pathway (H), and integrin 3 pathway (I). Ordinate in bubble plot (A) is GO terms, the color of the bubble corresponds to the magnitude of the correlation. In network plots (B), orange color dots represented the detail genes, and Navy blue circles represented the detail pathways. In the bubble plot (C), Cyan dots represented BP pathway, orange circles represented CC pathway, and the Navy blue circles represented MF pathway. In the circle plot, orange dots represented upregulated genes (logFC > 0), Navy blue dots represented downregulated genes (logFC < 0).