Research Paper Volume 15, Issue 15 pp 7424—7439
DNA methylation-mediated high expression of CCDC50 correlates with poor prognosis and hepatocellular carcinoma progression
Figure 6. DNA and RNA methylation analysis of CCDC50 in HCC. (A) Correlation between m6A-related modulator genes and CCDC50 in LIHC. (B, C) The level of DNA methylation of CCDC50 in liver cancer tissue was significantly lower than that in normal liver tissue, and was negatively correlated with liver cancer metastasis. (D) The level of DNA methylation of CCDC50 was significantly negatively correlated with the expression of CCDC50 in HCC. (E, F) Correlation between DNA methylation of CCDC50 and prognosis in LIHC. (G) Correlation between DNA methylation of CCDC50 and the level of immune cell infiltration in LIHC. RSEM is a software for quantifying gene expression based on STAR sequence comparison. ns, p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001.